POLE and cancer: For comparison, of 127 MSI‐H ECs without a POLE mutation (MSI‐H ECs), only one case had a TMB above 100 mut/MB (median 21.5) or a C>A proportion above 20% (median 9.1%); these cancers also had low T>G proportions (median 1.4%),a higher C>G proportion (median 1.5%,) and a high indel proportion (median 24.8%) (Table 2).