POLE and neoplasm: In contrast, of the 18 tumours with a non‐hotspot POLE EDM, seven scored ≥ 4 points (all of which carried mutations recurrent in the TCGA or COSMIC EC databases: F367S, L424I, M295R, P436R, M444K, D368Y), five scored 3 points (four of which carried recurrent mutations: A465V, L424V, T278M, L424I; one with a non‐recurrent A428T substitution), and six scored ≤ 2 points (one of which had a recurrent mutation).