Comparing these with the 23 tumours with non‐exonuclease domain mutations, non‐hotspot POLE exonuclease domain‐mutant ECs had a higher TMB (median 164.4 versus 42.8 mut/Mb) and C>A proportion (median 20.2% versus 10.8%), and a lower C>G proportion (median 0.5% versus 1.0%) and indel proportion (median 5.2% versus 9.5%) (Table 2). Here, POLE is linked to neoplasm.