However, increasing genetic instability decreases \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$\rho _{NK}^{*}$\end{document}ρNK∗ in a quasi-linear way, so that after a possible MMR knockout, a recruitment rate within 10−2day−1 would suffice for cancer clearance, indicating the possibility of a combination therapy enhancing both mutagenesis and NK cell activation [28]. This evidence concerns the gene MRC1 and cancer.