Chronic ethanol exposure also increased phosphorylation of tau, another toxic protein associated with AD [29], in both mice groups ethanol-induced decrease in synaptophysin, a marker for synaptic health, that was significantly greater in ALDH2*2/*2, consistent with a higher sensitivity to chronic ethanol exposure of these mice relative to WT mice (Fig. 3g-i). This evidence concerns the gene SYP and Alzheimer disease.