Using Alda-1, a previously characterized small molecule activator of ALDH2 that restores the activity of ALDH*2/*1 heterozygotic enzyme to WT levels [8], all the above defects observed in the fibroblasts of this AD patient were significantly corrected (Fig. 1e-g; Additional file 1: Figure S1C, D). The gene discussed is LDHA; the disease is Alzheimer disease.