Screening 20 AD patient-derived fibroblast lines, we identified ALDH2*2/*1 (heterozygote) carrier in one Japanese patient afflicted with Alzheimer’s disease (AG11369; onset at ~ the age of 50 years) (Fig. 1a), who had three siblings affected with dementia (AG10643, AG10644, and AG10646). Here, ALDH2 is linked to Alzheimer disease.