In NCI-H1975 tumor model, tumor weight in mice co-treated with VEGFR1-Fc and SIRPα-Fc was 56.08 ± 32.09 mg (P < 0.0001 versus VEGFR1-Fc cohort), while the tumor weight in VEGFR1-Fc group and the control were 412.15 ± 51.19 mg and 818.09 ± 97.57 mg, respectively (Fig. 4b). This evidence concerns the gene FLT1 and neoplasm.