As shown in (Additional file 1: Figure S1), anti-angiogenic treatment (VEGFR1-Fc fusion protein, or anti-VEGF antibody bevacizumab) could tentatively control tumor growth for about 2 to 3 weeks followed by resistance to anti-angiogenic therapy and robust tumor growth, and finally did not elicit significant survival benefits (Additional file 2: Figure S2). The gene discussed is VEGFA; the disease is neoplasm.