Disrupting CD47/SIRPα signaling transduction by blocking antibodies (Hu5F9-G4 and CC-90002) could increase macrophage phagocytosis of multiple tumor cells and has been proved as a promising immunotherapeutic method for melanoma, breast cancer, small cell lung cancer and acute myeloid leukemia [38, 39]. The gene discussed is CD47; the disease is melanoma.