The ten major hubs in the de novo network enrichment analysis have all been related to MS or autoimmune/brain diseases (Fig. 6): MS susceptibility genes (SH2B3 [3], RAB23 [50]), potential biomarkers (CSF2RB [70], ANXA2 [38]), or potential roles in inflammatory/brain diseases or MS pathogenesis (RAC2 [78], Smurf1 [62], TGFB1I1 [53], TRIM38 [35], TNFAIP3 [33], PRKCZ [51]). This evidence concerns the gene SMURF1 and brain disorder.