TNF and neoplasm: The acquisition of CD57 by terminal-differentiated Vδ2pos T cells is also associated with significantly impaired effector-functions in term of anti-tumor cytokines production (i.e. IFN-γ and TNF-α) and ability to degranulate (i.e. decreased amounts of cytotoxic CD107apos cells) when compared to CD57neg/Vδ2pos T cells (Fig. 2c).