Among the 20 studies reported in Table 5, the effectiveness of anti-IL-1 therapies in AOSD ranged from 50 to 100% (median 83.3%); the rate of remission ranged from 22.2 to 100% (median 70%) and the treatment failure rate from 0 to 50% (median 16.7%). This evidence concerns the gene IL1B and adult-onset Still disease.