For example, most of the individuals affected by Beckwith-Wiedemann syndrome (BWS) have altered DNA methylation of either the H19-IGF2:IG-DMR (also known as IC1) or the KCNQ1OT1:TSS-DMR (also known as IC2) both located on chromosome 11p15.5 that regulate two independent gene clusters [2]. This evidence concerns the gene IGF2 and Beckwith-Wiedemann syndrome.