PRDM5 and brittle cornea syndrome: Other novel variants already classified as pathogenic by Intervar, an ACMG variant classification tool, were observed in PRDM5 (homozygous variant: c.1036C > T; p.(Arg346Ter)) in patient P15 presenting with Brittle Cornea syndrome and in WRN (c.2313 T > A; p.(Cys771Ter)) associated with another already described nonsense variant in patient P8 presenting with classical Werner syndrome.