Overall, this study suggested the anti-allergic property of ethanol (80%) extract of M. oleifera leaves, seeds and pods, as well as the isolated compounds by stabilising mast cell from degranulation and inhibiting the early and late phases of allergic reaction in anti-DNP IgE sensitised RBL-2H3 cells induced by DNP-BSA. The gene discussed is IGHE; the disease is allergic disease.