APP and Alzheimer disease: Detailed below are our latest PhenT preclinical studies demonstrating inhibition of PNCD and neuroinflammation in mice challenged with mTBI; notably, this was cross‐validated in both AD transgenic (APP + PS1) mice subjected to mTBI40 and in controlled cortical impact (CCI) injury challenged mice,41 which is a well‐characterized animal model of modTBI.