Moreover, an increase in the number of Tsens is observed in all patients suffering from HPD.39 All in all, these considerations suggest that response to immunotherapy can either follow two possible pathways; one leading to the inactivation of Tsens and causing a cytotoxic response, or the other to overactivation which leads to the proliferation of Tsens and additionally, triggering a molecular compensatory response to PD‐L1 blockade and promoting tumor growth. This evidence concerns the gene CD274 and neoplasm.