PAKs, a member of the STE20 serine/threonine kinases family, play an important role in regulating the changes in actin cytoskeleton structure and cell morphology.37 PAK2, a member of PAKs family, is associated with malignant progression of human cancer.22 Recent study revealed that PAK2 could mediate tumour cell proliferation, invasion, apoptosis and so on.38, 39 We confirmed the oncogenic effect of PAK2 in COAD. The gene discussed is PAK2; the disease is colon adenocarcinoma.