PAK2 is a member of the P21‐activated kinases (PAKs) family of serine/threonine kinases.19 PAKs, the effectors of the Rho family of small GTPases, participate in a variety of cellular signalling pathways.20 Accumulating evidence suggests that overexpression of PAK2 is involved in signalling pathways related to malignant progression of many malignant tumours.21, 22 We also confirmed the oncogenic effect of PAK2 in COAD. This evidence concerns the gene MARK2 and colon adenocarcinoma.