The current review supports the assumption that metformin potentially has an anticancer effect via the mechanisms suggested by different studies, including impairing cellular metabolism and inhibiting oncogenic signaling pathways, like receptor tyrosine kinase, PI3K/Akt, and mTOR pathways and regulation of cancer stem cells (CSCs) and related pathways as recently reviewed by Saini and Yang [20] and Kheirandish et al. [21]. Here, AKT1 is linked to cancer.