INS and type 2 diabetes mellitus: Although greater insulin clearance on the day of dialysis may also influence the effectiveness of insulin and dialysis therapy improves uremia-associated insulin resistance [18], related studies, evaluating day-to-day variations of insulin needs among T2DM patients with ESRD receiving maintenance hemodialysis, showed a significant reduction of 25% in basal insulin requirements the day after dialysis compared with the day before [12].