Obese women with PCOS have decreased levels of sex hormone-binding globulin (SHBG), increased testosterone, more hirsutism, higher glucose levels, and increased insulin resistance, leading to a higher risk of menstrual irregularity, infertility, miscarriage, hypertension in pregnancy, gestational diabetes, premature delivery, biochemical and clinical hyperandrogenism, glucose-intolerance, type 2 diabetes, and the metabolic syndrome. The gene discussed is SHBG; the disease is Insulin resistance.