SRY and Infertility: The sSMC(Y) was identified as der(Y) (pter ⟶ q11.23) (SRY-), and its missing SRY gene might be translocated to the terminal of long arm in the “seemingly normal” chromosome Y. In our study, the combined application of traditional and molecular cytogenetic analysis plays a critical role in characterizing the presence, origins, and constitutions of marker chromosomes, which offers more detailed guidance and explanation in genetic counseling for the sSMC infertile carriers.