MYOF and neoplasm: MYOF can facilitate secretion of vascular endothelial growth factor A (VEGFA) (Figure 2), a key factor for angiogenesis, while MYOF silencing impairs exocytosis of VEGFA by blocking the fusion process of VEGFA-containing vesicles with plasma membrane, which reduces VEGFA secretion from tumor cells and in return attenuates tumor-related angiogenesis [68].