As TRAIL and interferon signalling frequently act concordantly and TRAIL itself belongs to the group of interferon-induced genes [12, 13], we wanted to investigate the influence of miR-221 on TRAIL effects in PCa and to evaluate the role of miR-221-mediated regulation of TRAIL signalling regarding the tumour suppressive function of miR-221. Here, TNFSF10 is linked to neoplasm.