Next, we examined the effect of the miR-221 target genes SOCS3 and PIK3R1 on TRAIL signalling by performing MTS assays of PCa cells with/without TRAIL administration after siRNA-mediated downregulation of both miR-221 target genes (Figures 4(a) and 4(b)). The gene discussed is PIK3R1; the disease is posterior cortical atrophy.