Three bioinformatics analyses indicated that CCNB1 was a key gene in BC, consistent with our findings [17–19]; however, other hub genes reported previously such as KIF4A, TPX2, BUB1B, CDK1, ISG15, KIF15, RAD54L, and TRIP13 were not identified in our analysis. The gene discussed is CCNB1; the disease is breast cancer.