Genes involved in the endoplasmic reticulum (ER) secretion pathways have been tested with success in zebrafish embryo as candidates for bone fragility in OI pathogenesis such as membrane bound transcription factor peptidase site 1 (MBTPS1) [17] and plastin-3 (PLS3) [18]. This evidence concerns the gene MBTPS1 and osteogenesis imperfecta.