SP7 and pregnancy disorder: Reporter lines using osterix/sp7 promoter as Tg (sp7:EGFP)b1212 [65], medaka osx-mCherry [66], and Tg (Ola. Sp7:NLS-GFP)zf132 [67] are useful to study the timing of the osteoblast differentiation, which is involved in craniofacial congenital malformations [68].