<b>Case Presentation:</b> A 50-year old Chinese female with resectable stage IB bilateral lung adenocarcinomas (ADCs) harbored <i>EML4</i> exon 6-<i>ALK</i> exon 19 and <i>TPM3</i> exon 8-<i>ROS1</i> exon 35 fusions in the right lower and the left upper tumors, respectively, identified by clinical NGS test targeting 425 cancer-relevant genes. This evidence concerns the gene TPM3 and cancer.