Yamamoto et al. (38) also used formalin-fixed and paraffin-embedded (FFPE) CRC tissue to perform liquid chromatography (LC)/mass spectrometry (MS) based on a global proteomic approach, revealing higher expression levels of cyclophilin A, annexin A2, and aldolase A in cancer compared to non-cancer regions (38). The gene discussed is PPIA; the disease is cancer.