Members of the serpin family, such as SERPINA1 (alpha-1-antitrypsin, A1AT), SERPINA3 (alpha-1-antichymotrypsin, AACT), and SERPINC1 (antithrombin-3, AT-III), have also been described as potential biomarkers of adenomatous polyps and colorectal carcinomas through analyses of serum samples by multiplexed quantification with an isobaric tag for relative and absolute quantitation (iTRAQ) (44). The gene discussed is SERPINC1; the disease is colorectal carcinoma.