However, subgroup analysis according to anatomical tumor origin revealed that ER positivity was significantly associated with a prolonged OS and RFS in women with tumors of pancreatic origin in univariable analysis (HR 0.18, 95% CI 0.05–0.60 and HR 0.18, 95% CI 0.05–0.68, respectively), but not in multivariable analysis. Here, ESR1 is linked to neoplasm.