In conclusion, our experimental results demonstrated that hydrostatin-SN10 had potent activity against pancreatitis-induced lung injury cells and significantly inhibited the IL-6-induced pancreatitis-associated lung injury cells associated with induction of apoptosis, oxidative stress, and inflammatory responses and inactivation of the IL-6/JAK2/STAT3 signaling pathway. Here, STAT3 is linked to pancreatitis.