LAMP2 knockdown impairs autophagy in adult rat ventricular myocytes and causes cell death at levels comparable to those associated with inhibition of autophagy [103], ablation of LAMP2 [89], or loss of LAMP2 [104] protein due to mutations in individuals with Danon disease [105], which is characterized by autophagosome accumulation in multiple tissues, including the myocardium, and by cardiomyopathy [104] and causes extensive myocardial fibrosis [106]. This evidence concerns the gene LAMP2 and Danon disease.