FMO5 and congestive heart failure: Ang-(1-7) in the PVN or RVLM increases NAD(P)H oxidase activity and superoxide anion level, and superoxide anions but not NO modulate the effects of Ang-(1-7) in the PVN or RVLM on sympathetic activity and blood pressure in normal rats or chronic heart failure rats [46, 47].