Thus, based on previous works performed on dystrophic murine models and human samples of DMD patients, we investigated the oxidative status of NSE/IL-6 muscle, in which the impact of increased levels of IL-6 cannot be biased against degenerating tissue and other related pathogenic mechanisms typical of dystrophic muscles, to better clarify the role of nonphysiologic levels of IL-6 in promoting the alteration of muscle oxidative balance. Here, IL6 is linked to Duchenne muscular dystrophy.