The autoimmunity directed against the COOH-terminal region of ZnT-8 is of particular prognostic significance; in particular, ZnT-8A-positive children who were homozygous for either arginine or tryptophan at position 325 (SLC30A-8), rs13266634, were found to have the greatest risk of type 1 diabetes progression compared to heterozygotes [89]. Here, SLC30A8 is linked to type 1 diabetes mellitus.