Autoantibodies against GAD, IA-2, IAA, and ZnT-8 are the most reliable biomarkers for type 1 diabetes in both children and adults [11, 16, 22, 68, 74, 82, 87] and are currently the only biomarkers that can distinguish LADA from phenotypically type 2 diabetes [13, 20, 82, 83, 88]. Here, PTPRN is linked to type 1 diabetes mellitus.