By using the Single Nucleotide Polymorphism Database (dbSNP data), three putative SNPs in hOGG1 (rs2072668), APEX1 (rs1130409), and XRCC1 (rs1799782) were selected and the genetic interactions of these three polymorphisms and their relation to NIHL risk among the Northern Han Chinese population were evaluated. The gene discussed is APEX1; the disease is noise induced hearing loss.