Furthermore, to evaluate the influence of the innate immune response marker TLR ligands on autophagy-mediated innate immune responses, Li et al. [34] transfected Atg7-specific siRNA into IEcs and determined the CXCL8 expression of the CRC cell HCT15 after exposure to various TLR ligands. This evidence concerns the gene ATG7 and colorectal carcinoma.