Lee et al. [16] developed an immunodeficient and skin-specific CXCL8-expressing transgenic model to evaluate colorectal cancer growth as well as metastasis and grafted syngeneic mouse colorectal cancer cells in CXCR2-knockout (KO) mice to study the contribution of CXCR2 to cancer progression in the microenvironment. This evidence concerns the gene CXCR2 and colorectal cancer.