CXCL8 and metastatic malignant neoplasm in the lymph nodes: Numerous clinical studies, including our research, have demonstrated that the elevated levels of CXCL8 in serum and tissues from colorectal cancer patients were related to the grade, stage, lymph node metastasis, and liver metastasis of CRC (P < 0.05), while the survival curve analysis also showed that the significantly decreased disease-free survival (DFS) and overall survival (OS) (P < 0.05) were highly related to the high expression of CXCL8 in CRC patients, which led to tumor progression and a poor prognosis [22, 35, 54, 55].