In addition to promoting angiogenesis, proliferation, invasion, migration, and survival of CRC cells, CXCL8 and its receptors have been known to induce the epithelial-mesenchymal transition (EMT) of CRC cells to help them to escape from host immunosurveillance and resist anoikis, which promotes the formation of circulating tumor cells (CTCs) and the colonization of distant organs (see Figure 1). This evidence concerns the gene CXCL8 and neoplasm.