TP53 and colorectal carcinoma: Interestingly, in order to get a more comprehensive analysis of the CRC-related gene network, Sonachalam et al. [32] integrated previous knowledge from protein interactions and gene signatures with gene set enrichment analysis (GSEA) and protein/gene network modeling to identify the gene network signatures for CRC from gene expression microarray data; from this integration, several important subnetwork signatures for CRC were discovered, such as the TP53 subnetwork and the CXCL8 subnetwork, which correspond to apoptosis and the immune response, respectively.