As a result, the CRC cells treated with the TLR ligands could produce considerable amounts of CXCL8, but CXCL8 expression was downregulated, and after inhibiting Atg7, it was found that CXCL8 may be involved in survival mechanisms within the downstream signaling pathways of autophagy [34]. Here, CXCL8 is linked to colorectal carcinoma.