CXCL8 and neoplasm: In addition, to study the role of CXCL8-CXCR1/2 in the growth of colorectal liver metastasis, Varney et al. [59] established mice whose spleens were injected with KM12L4 tumor cells to induce colorectal cancer, and a CXCR1/2 antagonist was used to interrupt the CXCL8-CXCR1/2 signal.