In the adhesion assay of tumor cells to endothelial cells, Li et al. [26] found that when CXCL8 mRNA and protein expression in the CRC cells was higher, the CRC cells more strongly adhered to the endothelium (EC), and the permeability of the CRC cells was enhanced, proving the role of CXCL8 in the adhesion processes of colon cancer cells to endothelial cells. Here, CXCL8 is linked to colonic neoplasm.