However, decreased expression of E-cadherin and increased expression of vimentin and/or beta-catenin, a total EMT-like phenotype in CRC cells, were obvious when another chemokine CCL20 was costimulated with CXCL8 (P < 0.01), and the process occurred along with the activation of the PI3K/Akt-ERK1/2 signaling pathway. The gene discussed is CDH1; the disease is colorectal carcinoma.