CXCR2 and colorectal cancer: In addition, to determine the association with colorectal cancer risk and overall survival, Bondurant et al. [65] detected genetic variations in genes from various anti-inflammatory and proinflammatory interleukins, finding that CXCL8, CXCR1, and CXCR2 were all significantly associated with the risk and poor prognosis of colorectal cancer, which was significantly associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen.