The possible strategies of targeting CXCL8-CXCR1/2 signaling in CRC include indirect strategies (e.g., NF-κB inhibitors and anti-inflammatory medications) and direct CXCL8 or CXCR1/2 blocking (e.g., neutralizing antibodies, small-molecule receptor antagonists, and siRNA strategies). Here, CXCL8 is linked to colorectal carcinoma.