Among these genes, six chemokines, including CXCL8, matrix metalloproteinase7 (MMP7), and EMT-related molecules, showed significant upregulation at the tumor front; nevertheless, the fold changes of MMP7 and EMT-related molecules were smaller than those of CXCL8, indicating that CXCL8 was more important than MMP7 and EMT-related molecules in the process of cancer cell invasion and metastasis distance. Here, CXCL8 is linked to cancer.