Also in the CXCL8 transgenic model, Asfaha et al. [39] found that the high CXCL8-expressing transgenic mice were more likely to develop colorectal tumors when fed azoxymethane and polyglucosan sodium sulfate, and the most import factors in promoting the tumor progression were the immature myeloid cells accumulated in the tumor microenvironment as well as the CXCL8 secreted by these immature myeloid cells. The gene discussed is CXCL8; the disease is colorectal neoplasm.