CXCL8 and melanoma: Additionally, in the parallel-plate flow assay, Liang et al. [27] discovered that tumor-liberated CXCL8, regulated by various shear stresses, could induce melanoma cell-PMN interactions mediated by the binding between intercellular adhesion molecule-1 (ICAM-1) on melanoma cells and β2 integrins on PMNs, which facilitate melanoma cell adhesion to the EC.