In the breast cancer lung metastasis model of mice, Wculek and Malanchi [42] found that before breast cancer cells infiltrated the premetastatic lung tissue, CD11b+Ly6G+ neutrophils, the mainly excretive cells of CXCL8, accumulated in the lung first and then facilitated the metastatic cancer cell transfer to the lung. This evidence concerns the gene CXCL8 and breast carcinoma.