Meanwhile, the expression level of MIC-1 plays a significant role in differentiating T2DM cases from controls; the combined sensitivity, specificity, and odds ratio were 0.83 (95%CI = 0.72‐0.90), 0.59 (95%CI = 0.45‐0.72), and 1.64 (95%CI = 1.35‐1.99), respectively. The gene discussed is GDF15; the disease is type 2 diabetes mellitus.