Our preliminary data obtained using newly available fish transcriptomes in public databases suggest that the carcino-evo-devo genes described in this paper include TSEEN genes (e.g. lepa), cancer/testis antigen genes (e.g. ccr11.1), carcino-embryonic genes (e.g. ephb3a) and genes expressed in normal fish tissues other than liver (e.g. id2a, reck). The gene discussed is RECK; the disease is cancer.