This aspect is interesting as the formation of a ternary p27(kip1)/Cyclin D3/Cdk4 complex was recently described [43], and therapeutic targeting of the cyclin D3: CDK4/6 complex in T-cell leukemia envisioned as an efficient treatment for pediatric and adult T-cell leukemia where rapid cell cycle arrest in both mouse and human T-ALL cell lines was observed [44]. Here, CDK4 is linked to acute lymphoblastic leukemia.