ALOX5 and polyarticular arthritis: In vitro studies have shown that D. thollonii has a very strong anti-inflammatory property: inhibition of protein denaturation, inhibition of 5-LOX, inhibition of COX and ROS and in vivo studies that have shown antiarthritis activity of the plant on a zymosan-induced monoarthritis model and a model of CFA-induced polyarthritis in the rat.