In 2005, Zhuo et al., using polymerase chain reaction-reverse dot blot (PCR-RDB) and DNA direct sequencing analyzed Chinese subjects (15 patients with keloid and 15 healthy controls) and revealed that the frequency of both p.Pro72 TP53 allele and p.Pro72 TP53 homozygous genotype in keloid patients was significantly higher than that in the controls [11]. Here, TP53 is linked to keloid.