Additional signaling networks that are also implicated in social behavioral deficits in autism include AVB3-INTEGRIN (Schuch et al., 2014; Dohn et al., 2017; Gabriele et al., 2019), PI3K-ERBB2/4 (Pinto et al., 2010), SEMA3A-PKA, and REELIN signaling (De Rubeis et al., 2014; Lammert et al., 2017; Stessman et al., 2017). This evidence concerns the gene RELN and autism.