Many studies have shown that the most abundant peanut-based allergens (Ara h 1 and Ara h 3 but, Ara h 2 and Ara h 6) bind strongly with peanut allergic IgE and release basophils mediators, which were confirmed in vitro (de Jong et al., 1998; Koppelman et al., 2005; Palmer et al., 2005; Porterfield et al., 2009) and in vivo (Koppelman et al., 2003; Koppelman et al., 2005; Peeters et al., 2007) with regards to food allergy (Porterfield et al., 2009). The gene discussed is IGHE; the disease is food allergy.