Accordingly, in an earlier study we found that low levels of adiponectin in CVID are accompanied by up-regulation of AdipoR1 and AdipoR2 and, vice versa, that high serum levels of adiponectin in autoimmune disorders result in the down-regulation of AdipoR1 and AdipoR2 (5). Here, ADIPOR1 is linked to common variable immunodeficiency.