In the attempt to shed further light on the role of adiponectin in CVID, we analyzed the expression profile of AdipoR1, AdipoR2 and T-cadherin on peripheral blood mononuclear cells (PBMC) from 18 treatment-naïve CVID patients, before and 24 h after the first Ig infusion. This evidence concerns the gene ADIPOR2 and common variable immunodeficiency.