TNFRSF1A and autoinflammatory syndrome: Moreover, endoplasmic reticulum stress has long been recognized as a key feature in the pathogenesis of monogenic and/or polygenic autoinflammatory syndromes including TNF-associated periodic syndromes (TRAPS) whereby mutations in genes encoding the TNF receptor (TNFR) results in the accumulation of misfolded TNFR species and subsequent activation of the UPR (69–71).