NCS1 and Parkinson disease: KChip3 (also named Calsenilin or DREAM) has overlapping functions with NCS-1 (Naranjo and Mellstrom, 2012; Burgoyne et al., 2019), and not only constitutes a beta subunit for Kv4.3 channels (An et al., 2000), that are involved in PD pathology (Subramaniam et al., 2014; Dragicevic et al., 2015), but it can also shuttle from the plasma-membrane to the nucleus, and act as a Ca2+ dependent transcription repressor by direct DNA binding (Carrion et al., 1999; Mellstrom and Naranjo, 2001; Gomez-Villafuertes et al., 2005; Mellstrom et al., 2014).