Furthermore, especially in SN DA neurons, NCS-1 inhibits their stressful activity in a Ca2+ and Cav dependent fashion, by stimulation of inhibitory, K+ channel coupled dopamine D2-autoreceptors (Kabbani et al., 2002; Dragicevic et al., 2014; Robinson et al., 2017), and NCS-1 mRNA levels are elevated in remaining human SN DA neurons from post-mortem PD brains (Dragicevic et al., 2014). The gene discussed is NCS1; the disease is Parkinson disease.