Mainly, they display slightly impaired insulin and somatostatin secretion (Jing et al., 2005; Zhang et al., 2007), mild cardiac arrhythmia (Weiergraber et al., 2005), and they are less prone to epilepsy (Weiergraber et al., 2007, 2010; Dibue-Adjei et al., 2017). This evidence concerns the gene INS and chronic obstructive pulmonary disease.