A different NCS-1 KO mouse strain, lacking exon 1 and resulting in disrupted NCS-1 protein, displayed an anxiety- and depression-like phenotype, reduced novelty-induced exploratory behavior (de Rezende et al., 2014), as well as reduced stress tolerance in cardiomyocytes due to dysfunctional mitochondrial detoxification and Ca2+ dependent pathways (Nakamura et al., 2016, 2019). The gene discussed is NCS1; the disease is depressive disorder.