In addition, HCC is strongly correlated with abnormalities of signal transduction network that regulate self-renewal ability, proliferation and differentiation capacity of stem cell, for example, MAPK, mTOR, Notch, and Wnt/β-catenin pathways or another cytokine such as HGF, IGF, VEGF, and PDGF signaling [14, 15]. This evidence concerns the gene MTOR and hepatocellular carcinoma.