Overexpression of cir-ITCH can suppress the growth, invasion and migration of bladder cancer cells, and further confirm that cir-ITCH targets miR-17 and miR-224, up-regulates the target genes p21 and PTEN of mi R-17 and mi R-224, thus suppressing the growth, invasion, migration and metastasis of cancer cells [36]. Here, PTEN is linked to urinary bladder cancer.