ITCH and cancer: In esophageal, colon and lung cancer, cir-ITCH binds to MI R-7/mi R-17/mi R-214 through molecular sponge to form cir-ITCH-mi RNA-7/mi R-17/mi R-214-ITCH regulatory signal axis, up-regulates the expression of ITCH, promotes the ubiquitination degradation of DVL2, inhibits the classical Wnt/β-catenin signaling pathway, and thus inhibiting the growth of cancer cells [19, 20].