In present study, we confirmed that KCNQ1OT1 exhibited abnormally high expression in BC tissues and cell lines, besides, BC patients with advanced stage (III/IV) enjoyed higher level of KCNQ1OT1 than those with early stage (I/II), which was closely associated with tumor cell biological function and pathological processes. This evidence concerns the gene KCNQ1OT1 and breast cancer.