CD8A and neoplasm: We observed the percentage of IFN-γ producing tumor infiltrating CD8+ T cells in IL-2/S-15/Akti group was significantly higher than that in IL-2 group (P < 0.001), IL-2/S-15 group (P < 0.01) and IL-2/Akti group (P < 0.05) at day 25 (Fig. 5).