The percentage of IFN-γ producing tumor infiltrating CD8+ T cells in IL-2 group was significantly lower than that in IL-2/Akti group (P < 0.05) and IL-2/S-15 group (P < 0.05), but there was no significant difference between IL-2/Akti and IL-2/S-15 group. The gene discussed is IL2; the disease is neoplasm.