E2F1 and cervical carcinoma: Interestingly, overexpress E2F1 or Myc could accelerate cervical cancer cells’ proliferation as compared to their normal controls, suggesting the oncogenic function of E2F1 and Myc in cervical cancer development (Fig. 6b); intriguingly, either overexpression of E2F1 or Myc in FTO deficient cervical cancer cells could completely re-establish the proliferation capacity to equivalent levels as compared to FTO functional control cells (Fig. 6b).