The aim of this paper was to investigate the biological role and molecular mechanism of LINC01006 in PC, and it was verified that LINC01006 functioned as a sponge of miR-2682-5p and regulated HOXB8 expression to promote cell growth and metastasis in PC, offering a novel agent for the treatment of PC. Here, HOXB8 is linked to pachyonychia congenita.