FBN1 and skeletal dysplasia: On the other hand, FBN1 mutations also cause various skeletal dysplasia, including Acromicric dysplasia (MIM #102370), Geleophysic dysplasia 2 (MIM #614185), Marfan lipodystrophy syndrome (MIM #616914), and Weill–Marchesani syndrome 2 (MIM #608328).