Microtubule-associated serine/threonine kinase like (MASTL) induced CRC progression and chemoresistance by activating the β-catenin signalling pathway.45 The ring finger protein 6(RNF6)-mediated degradation of transducin-like enhancer of split 3 (TLE3) remarkably impeded the binding of TLE3 with TCF4/LEF, which promoted the recruitment of β-catenin to TCF4/LEF and activated β-catenin signalling in CRC.46 Our study demonstrated that PLAGL2 was significantly associated with the expression of β-catenin. Here, RNF6 is linked to colorectal carcinoma.