The β-catenin nuclear accumulation can be observed in approximately 80% of CRC specimens.10 β-Catenin that is located in the nucleus functions as a coactivator of T-cell and lymphoid enhancer factors (TCF–LEFs) to transcriptionally activate downstream genes.9 The abnormal activation of β-catenin/TCF signalling has been implicated in various tumours, most notably CRC. The gene discussed is HNF4A; the disease is neoplasm.