PLAGL2 and cancer: PLAGL2 was significantly overexpressed in CRC specimens relative to that in matched tissues (Fig. 1a and Supplementary Fig. 1A), which is consistent with the results derived from the Oncomine cancer microarray database (https://www.oncomine.org/resource/main.html)23 and the GEPIA database (http://gepia.cancer-pku.cn/detail.php)24 (Fig. 1b, c).