Previous studies have demonstrated that PLAGL2 impeded differentiation in neural stem cells and gliomas.12 PLAGL2 modified the proliferation of haematopoietic progenitor and leukaemia cells,15 and promoted cell migration and invasion in various cancers.16,35 The data in our present study showed that PLAGL2 promoted the proliferative and metastatic properties of CRC cells in vitro. Here, PLAGL2 is linked to central nervous system cancer.