Nevertheless, it has been increasingly accepted that EMT also includes a range of hybrid states, a phenotype known as “partial EMT’’ (P-EMT).31–33 Because p-EMT is not well defined at the molecular level,34 it is not clear whether this hybrid status represents an intermediate phase in the process of a mesenchymal transition or its own terminal state.31 Therefore, our research mainly focused on the molecular mechanisms of PLAGL2 inducing EMT and an aggressive phenotype in CRC. The gene discussed is PLAGL2; the disease is colorectal carcinoma.