Grainyhead-like-2 (GRHL2) is a broad suppressor of oncogenic EMT by inhibiting the TGF-beta signalling pathway and directly inhibiting ZEB1 expression.25 ZEB1 repressed GRHL2 expression by directly binding to the GRHL2 promoter.25–27 The GRHL2-ZEB1 bidirectional negative feedback loop drives EMT or MET in response to extracellular signals.26–28 It was worth exploring Whether GRHL2-ZEB1 reciprocal feedback loop was involved in PLAGL2-mediated EMT process and tumorigenesis of CRC. This evidence concerns the gene GRHL2 and colorectal carcinoma.