ZEB1 and colorectal carcinoma: Recent studies have described ZEB1 as a vital activator of the EMT process that mediates the EMT-related protein expression.36,37 ZEB1 also induced tumorigenesis by impeding the expression of stemness-inhibiting microRNAs.38 In addition, ZEB1 was involved in 5-fluorouracil resistance in CRC cells.39 Given that ZEB1 plays a crucial role in CRC progression, it is urgent to reveal the potential signalling pathway that regulate the expression of ZEB1.