Of interest, sons of women with PCOS examined over pubertal development exhibit higher cholesterol and LDL levels, but do not present with any differences in circulating concentrations of LH, FSH sex hormone-binding globulin, testosterone, androstenedione (A4), 17α-hydroxyprogesterone (17-OHP) or AMH49. The gene discussed is SHBG; the disease is polycystic ovary syndrome.